Sustanon 250 is a blend of four esterified testosterone compounds mixed in a certain proportion. A typical composition of this highly potent testosterone blend is: 100mg Testosterone Decanoate, 60mg Testosterone Isocaproate, 60mg Testosterone Phenylpropionate, and 30mg Testosterone Propionate to form 250mg of mixed testosterone esters, which explains the number suffix of 250 in Sustanon 250 . This mixture of compounds allows for immediate testosterone release followed by more gradual release, which means that users of Sustanon 250 do not have to suffer from pain at injection site.
Sustanon 250 is identified through its molecular formula C19H28O2 and has the chemical name 4-androsten-3-one-17beta-ol and 17beta-hydroxy-androst-4-en-3-one. It is also referred to as Sostenon as well as Dura-Testin, and is a widely used anabolic steroid and performance enhancing drug. Its detection takes between two and three months and the drug’s active life is anywhere between 15 and 18 days. Sustanon 250 is mostly available as a clear glass vial which contains 1mL of yellow oily solution .
Sustanon 250’s History
The pharmaceutical company behind Sustanon 250’s development is the Netherlands-based Organon International, which was acquired by Schering-Plough Corporation in November 2007. The anabolic steroid made its entry into the market in the 70s. The original idea that drove the makers of Sustanon 250 was to come up with a testosterone mixture that would offer greater benefits over any single testosterone product in clinical environments. Convenience was another driving force in the development of the powerful drug as fewer injections of Sustanon 250 are needed compared to mono esterified testosterone drugs such as Testosterone Propionate and Testosterone Decanoate, to name a few .
Perhaps, the most extensively used testosterone preparation by athletes and bodybuilders, Sustanon 250 has never been granted usage or sales permission in the US. Despite this it continues to be a very popular drug in the rest of the world. But what makes Sustanon 250 so popular? The answer is not its potency, which contrary to popular opinion is no more than that of single esterified preparations of testosterone. Esters appended to anabolic steroids only have the capacity to influence their release time and half-life, and do not have any direct bearing on their strength. The true reason for Sustanon 250’s success and widespread popularity is that the user stands to obtain more quantity of steroid for the same price than other testosterone preparations.
Though this anabolic steroid has enjoyed unprecedented success among athletes and bodybuilders, they were hardly the target audience the makers of Sustanon 250 had in mind while developing the drug. Instead, they were aiming for increased comfort of patients in need of medical treatment by providing them a convenient dosing schedule. Patients who are being administered Sustanon 250 don’t have to constantly worry about their dose, as one steroid injection every 21-28 days usually proves sufficient for their needs.
Pharmacological Characteristics of Sustanon 250
Sustanon 250 is made up of four testosterone esters, each having its own action duration. With its different testosterone variants, Sustanon 250 is designed for providing a gradual release of testosterone into the blood plasma, which is helpful in bringing down the frequency of dosage. Testosterone by itself, without any esters attached has a half-life in the range of 2-4 hours. However, when esters attach themselves to this natural hormone they slow down testosterone’s release. For example, with a Propionate ester attached to it, the resulting testosterone preparation has a half-life of 4.5 days, which is significantly longer than normal testosterone’s half-life. The four esters of Sustanon 250 undergo hydrolysis, i.e. are broken by the action of water, almost immediately after entering general circulation to leave the natural steroid hormone, testosterone, free in the bloodstream.
A dose of Sustanon leads to the increase of testosterone in the blood plasma. Peak-levels of about 70 nmol of testosterone are reached within 24-48 hours after Sustanon 250 has been administered. Testosterone levels return to normal range after 21 days in males.
Administration of Sustanon 250 injections results in significant increase in testosterone, oestradiol, dihydrotestosterone, and androstenedione concentrations in the blood plasma. There’s also a drop in the level of SHBG (sex hormone-binding globulin). FSH (Follicle-stimulating hormone) and LH (Luteinising hormone) are returned to their expected range following the administration of Sustanon 250.
In men suffering from hypogonadism – diminished functional activity of testes – treatment with this popular Testosterone preparation results in marked improvements in testosterone-deficiency symptoms . There are several other health advantages such as increased lean-body mass and bone-mineral density. Enhanced sexual function is yet another advantage of the treatment – this includes both erectile and libido functions.
Treatment leads to a reduction in triglycerides, and serum HDL-C (High Density Lipoprotein-Cholesterol) and LDL-C (Low Density Lipoprotein-Cholesterol), while increasing hematocrit and hemoglobin, but has little to no effect on PSA (Prostate Specific Antigen). No side effects have been reported for prostate symptoms, but treatment using Sustanon 250 can increase the size of the patient’s prostate.
When administered with androgens, hypogonadal patients also suffering from diabetes show improved sensitivity to insulin. A lowering of glucose level in the bloodstream of patients has also been reported. The combination of Sustanon 250 and androgens has also proved effective in inducing masculinity in female-to-male transsexuals.
Important Particulars for Sustanon 250
Androgen/testosterone-replacement therapy might be suggested for male patients suffering from hypogonadism. The following hypogonadal disorders could call for treatment using Sustanon 250: eunuchoidism, hypopituitarism and castration. Testosterone-replacement therapy may also be indicated because of male androgen/testosterone deficiency. The drug may also be employed as supportive therapy for female-to-male transsexuals .
Dosage varies from one individual to the next, and will depend on the specifics of a patient’s medical case and history. However, according to the electronic Medicines Compendium or eMC, the following dosage levels of Sustanon 250 are usually prescribed:
For Adults – A 1ml injection of Sustanon, once in three weeks is considered adequate.
For Children – Safe dosage limits have yet to be established for children.
Female-to-male Transsexuals – Specialist centers use dosage ranging from 1ml injection every couple of weeks to 1ml injection once in four weeks.
Mode of Administration
Deep-intramuscular injection is how the testosterone should be administered to the patient.
Situations When Sustanon 250 Should Not Be Used
Contra-indications for the drug include – history of breast or prostate cancer in the patient, hypersensitivity to one or multiple active components of the drug (patients who are allergic to soya or peanuts should not be administered Sustanon 250), and lactating women.
Side-Effects and Necessary Precautions
Testosterone therapy using Sustanon 250 can have the following side-effects:
In case of adverse reactions because of testosterone therapy, treatment has to be interrupted and should be resumed only after all symptoms of ill-effects have disappeared, and at a recalibrated dosage level .
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